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Serie A leaders Inter return after the mid-season break with a tricky trip to Stadio San Paolo.

Antonio Conte will be unable to call upon D'Ambrosio for the game after an MRI scan on Thursday confirmed the wing-back has sustained a thigh strain.

The 31-year-old suffered the injury in training and will be reassessed next week.

Napoli has a fitness concern of its own after Spain international Fabian sat out a training session on Friday (AEDT) due to illness.

The Partenopei ended an eight-game winless league run with a 2-1 victory at Sassuolo on December 22, Gennaro Gattuso's first victory at the helm, and will hope to close the 11-point gap to the top four with a positive result.