Ewels was shown the earliest red card in championship history for a dangerous tackle on James Ryan and it looked like the Red Rose would be in for a painful evening when James Lowe crossed early on.

Yet Eddie Jones' side, roared on by a raucous crowd, produced an inspired display despite being a man down, only trailing 15-9 at half-time in an absorbing contest after three Marcus Smith penalties and a Hugo Keenan try for the visitors.

Smith's fourth and fifth penalties brought a spirited England level, but a Johnny Sexton penalty 15 minutes from time put Ireland back in front before late tries from Jack Conan and Finlay Bealham sealed a victory that moved Andy Farrell's men two points adrift of leader France.

Ireland is at home to Scotland in its last match of the tournament next Sunday (AEDT) and will be hoping for a favour from England when it does battle with Les Bleus in Paris.

Ewels's participation was over soon after it started, with referee Mathieu Raynal giving the lock his marching orders after he clashed heads with Ryan attempting a tackle.

With a dazed Ryan unable to continue, Sexton slotted over the resulting penalty and Lowe raced down the left to score the opening try in a dramatic start after taking a pass from Josh van der Flier.

Caelan Doris had a try ruled out due to a Garry Ringrose knock-on and Tom Curry limped off before England started to dictate the game despite being a man down, Smith reducing the deficit with two penalties and also missing one.

The Red Rose pack dominated – wing Jack Nowell playing his part in the scrum – but Jamison Gibson-Park's quick free-kick opened the door for Keenan to crash over before Smith's third penalty on the stroke of half-time made it 15-9.

There was another blow for England when Kyle Sinckler failed a head injury assessment at half-time, Will Stuart replacing him, but another Smith penalty left them only three points down.

Five-eighth Smith brought them level midway through the second half with another penalty won in a ferocious scrum, but Sexton booted Ireland back into the lead and converted after Conan crashed over from close range after 71 minutes.

Bealham added insult to injury as the pressure told on weary England late on, barging over in the corner and Sexton took his points tally with the boot to 12 by adding the extras.